Cedars-Sinai provides virtually every known gastroenterologic analytical procedure and treatment for digestive diseases and disorders. The Bilsborough Laboratory's Inflammatory Bowel Diseases Drug Discovery and Development unit is composed of research scientists and clinicians with experience in both the biopharmaceutical industry and clinical research.
The Bilsborough Lab's approach is to identify IBD patients with similar types of disease to better understand disease pathology and devise more effective treatments. IBD3 is a unique concept by design, in which an industry-caliber target discovery and development unit is integrated with an academic research program to accelerate the pace at which scientific findings are brought to bear on patient care. Research in the Bilsborough Lab seeks to personalize drug development and ensure that each patient receives the therapeutic treatment most suited to his or her disease. In doing so, we seek to accelerate the drug discovery process and help put new and effective therapeutic drugs on the market. To learn more, please visit: Bilsborough Research Lab | Cedars-Sinai (cedars-sinai.edu)
The Biomedical Technician participates on projects to develop and achieve compliance with all Federal and State accrediting agency requirements, including Food and Drug Administration (FDA) requirements for good manufacturing practices (GMP) for cellular products in Cedars-Sinai Biomanufacturing Center (CBC). Performs tissue culture and aseptic techniques for developing and processing clinical grade and research grade cellular products in accordance to established standard operating procedures (SOP). Performs process development, validation, and qualification for cellular production in GMP/good laboratory practice (GLP) environment. Responsible for lab maintenance, handling fresh and frozen cellular specimens and products using aseptic techniques, writing and recording controlled documents, and autoclaving for production. Performs all current good manufacturing practice (cGMP) related activities strictly according to SOPs, with accurate documentation, and assists quality control team with requried testing activates. Contributes to the success of projects by providing good documentation, communication skills, and attention to detail. Performs cellular, micro- and molecular biology procedures including Western blot, Northern blot, DNA/RNA, PCR, protein extraction, cell culture, Immunohistochemistry, and staining.
Primary Duties and Responsibilities:
Performs a variety of process development tasks for multiple clients following standard operating procedures that will be different for each project based on the type biomedical work.
Writes and maintains good documentation in laboratory notebooks, data record/transfer, SOPs, and batch records.
Drafts standard operating procedures and maintains computer database.
Verifies samples received, logs samples into systems, and transports to appropriate environment within the facility for storage following SOPs.
Performs lab maintenance duties, including glassware cleaning and sterilization.
Maintains lab equipment and related records.
Prepares cGMP production room, maintains material inventories, and places orders for equipment and supplies
Assists in the operation of specialized equipment and machinery.
Ensures all activities comply with regulatory guidelines and safety standards.
Performs RNA or DNA isolations using commercial kits, glass washing and autoclaving, making media and bacterial culture plates, data analysis using Excel or GraphPad Prism.
Prepares graphs and creates PowerPoint slides to present data to others.
Participates in lab and department meetings, researching (NCBI/PubMed), and understands experimental particulars in the scientific literature as necessary to supplement training.
Bachelor of Science in Molecular Biology, Biochemistry or related science/engineering field.
Experience and Skillset:
One (1) year of experience working in a lab environment required.
Must have experience working in an aseptic environment, with biosafety cabinets and experience working with human and animal tissues.
Tissue culture experience required (aseptic technique); molecular biology (PCR or molecular cloning) experience required, protein or DNA gel electrophoresis experience preferred but can be trained.
Working Title: Biomedical Technician - Bilsborough Lab
Department: Home Dept - Gastroenterology
Business Entity: Academic / Research
City: Beverly Hills
Job Category: Family & Function, Academic / Research
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major t...eaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.